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We compared and analyzed the Biological Agent Laboratory Biosafety Category list and the defining criteria according to the World Health Organization (WHO), the National Institutes of Health (NIH), the European Union (EU) and China.
Biological agents are assigned to risk groups 1 through 4, with agents that are not associated with disease in healthy adults assigned to risk group 1, and with each successive risk group 2–4 posing a greater risk to human health.
4 ημέρες πριν · Note: In September 2022, four additional individual Group 1 agents were created by splitting up some existing agent groupings because not all agents in the groups had the same cancer sites with sufficient and limited evidence for cancer in humans. Three strains of human papillomavirus (HPV) were split from a larger grouping of HPV strains.
Explain the concept of selective toxicity. An effective antimicrobial agent that must be more toxic to a pathogen than a pathogens host; drugs with excellent selective toxicity block the synthesis of the bacterial cell wall (penicillins); human cells lack the chemical peptidoglycan and are unaffected by the drug. 2.
The agents are classified as “carcinogenic to humans” (Group 1), “probably carcinogenic to humans” (Group 2A), “possibly carcinogenic to humans” (Group 2B), “not classifiable as to their carcinogenicity to humans” (Group 3), or as “probably not carcinogenic to humans” (Group 4).
20 Οκτ 2019 · The purpose of this paper is to provide an overview of the biological mechanisms by which Group-1 human carcinogens exert their carcinogenic effects in humans, focusing specifically on the 86 distinct Group-1 human carcinogens. For simplicity, these will be referred to as ‘agents’ in the review.
The agents documented and listed as carcinogenic to humans (Group 1) in Volume 100 of the IARC Monographs show several key characteristics that distinguish them as carcinogenic agents. Many appear to act via multiple mechanisms, causing various biological changes in the multistage process of carcinogenesis.
