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19 Ιαν 2023 · Digoxin has a narrow therapeutic index. The recommended serum levels stand between 0.8 to 2 ng/mL. When measuring a digoxin serum level, drawing blood at least 6 to 8 hours after the last dose is essential. The toxicity increases as the serum drug levels increase above 2.0 ng/mL.
1 Νοε 2022 · • Narrow therapeutic index (NTI) drugs are drugs where small differences in dose or blood concentration may lead to serious therapeutic failures and/or adverse drug reactions that are...
4 Μαρ 2023 · Digoxin may improve the quality of life in CHF patients, but it does not confer a mortality benefit, and its narrow therapeutic index limits its utility. Digoxin toxicity can present acutely, by an intentional or accidental overdose (i.e., therapeutic misadventure), or chronically, such as when patients on digoxin develop an acute kidney injury.
Digoxin is the oldest cardiac medication used in contemporary medicine. With a complex pharmacokinetic profile and narrow therapeutic index, its use in managing patients with atrial arrhythmias or heart failure can present a challenge to today's clinicians.
1 Αυγ 2024 · Digoxin, the oldest known cardiovascular drug, is still used today to treat heart failure and atrial fibrillation. Because it has a narrow therapeutic index and multiple interactions, it frequently causes toxicity with a wide range of symptoms and cardiac arrhythmias.
27 Φεβ 2008 · Its hemodynamic, neurohormonal and electrophysiologic actions make it a suitable adjunctive, evidence-based therapy for the above conditions. Its narrow therapeutic index and its toxicity, however, have become more relevant as aging, comorbid diseases, and polypharmacy make more patients vulnerable.
4 Αυγ 2021 · This differs from the Narrow Therapeutic Index drugs such as phenytoin and digoxin in that the latter drugs exhibit serious dose-limiting toxicities over their entire range of therapeutic doses and require for all doses either PK or PD monitoring, something that for aspirin is rarely done even at high doses.
