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19 Νοε 2022 · Diffuse midline glioma (DMG), formerly called diffuse intrinsic pontine glioma (DIPG), is a high-grade malignant pediatric brain tumor with a near-zero survival rate. To date, only radiation therapy provides marginal survival benefit; however, the median survival time remains less than a year.
Diffuse midline gliomas usually require additional treatments as well. In most cases, surgery is followed by radiation therapy. Chemotherapy is sometimes given with or after radiation. However, there is no standard chemotherapy regimen, and each plan should be tailored to the individual patient.
16 Απρ 2024 · Radiation therapy. For most DMG, substantive resection is generally impractical (except for the dorsally exophytic component of the tumor).
Color indicates radiation dose. Conventional radiotherapy, limited to the involved area of tumour, is the mainstay of treatment for DIPG. A total radiation dosage ranging from 5400 to 6000 cGy, administered in daily fractions of 150 to 200 cGy over 6 weeks, is standard.
3 Νοε 2023 · The standard therapy for newly diagnosed DMG patients is focal conventional fractionated radiation therapy in non-metastatic cases, with a total dose of 54–60 Gy administered over 6 weeks.
1 Ιουν 2023 · WHO updated nomenclature for DMG in 2021 to diffuse midline glioma H3 K27-altered[2], reflecting a broader molecular understanding of DMGs that recognizes alterations through other pathogenic mechanisms, including TP53, ACVR1, PDGFRA, EGFR, and EZHIP [2].
17 Απρ 2024 · There is currently no standard of care for DMG, and palliative radiation therapy has been proven to only extend survival by months. Our current study aims to report current treatment trends and predictors of the overall survival of DMG. Methods. We searched the National Cancer Database for adult patients treated for DMG from 2016 to 2020.
