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  1. Diffuse midline glioma (DMG), formerly called diffuse intrinsic pontine glioma (DIPG), is a high-grade malignant pediatric brain tumor with a near-zero survival rate. To date, only radiation therapy provides marginal survival benefit; however, the median survival time remains less than a year.

  2. 1 Ιουν 2023 · Diffuse midline glioma (DMG) is the leading cause of brain tumor-related deaths in children. DMG typically presents with variable neurologic symptoms between ages 3 and 10. Currently, radiation remains the standard therapy for DMG to halt progression and reduce tumor bulk to minimize symptoms.

  3. 21 Ιουν 2024 · Apatinib plus temozolomide could be an effective regimen with manageable toxicities and favorable efficacy and may outperform temozolomide monotherapy, particularly in newly diagnosed adults with tumors located outside the pons. The novel therapy deserves further investigation in adult DMG patients. Key points.

  4. Current research has revealed that aggressive brain tumor subtypes, such as DMG, have high myeloid signatures, low expression of immune modulatory factors, and minimal infiltration of lymphocytes and NK cells responsible for tumor elimination.

  5. 3 Νοε 2023 · The standard therapy for newly diagnosed DMG patients is focal conventional fractionated radiation therapy in non-metastatic cases, with a total dose of 54–60 Gy administered over 6 weeks.

  6. 4 Ιαν 2023 · In terms of radiotherapy techniques, passively scattered proton beam therapy (PSPT) provides lower doses of radiation to the healthy tissue around the tumor, and larger temporal lobe and ...

  7. 17 Απρ 2024 · There is currently no standard of care for DMG, and palliative radiation therapy has been proven to only extend survival by months. Our current study aims to report current treatment trends and predictors of the overall survival of DMG. Methods. We searched the National Cancer Database for adult patients treated for DMG from 2016 to 2020.

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