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The standard-of-care for newly diagnosed DMG patients is conventional fractionated radiation therapy, where a 54–60 Gy dose is delivered over 6 weeks [6, 7]. This provides only transient relief of symptoms in 70–80% of patients and a 3- to 4-month survival benefit [5, 8, 9].
- Pediatric Diffuse Midline Gliomas: An Unfinished Puzzle - PMC
Clinical and radiological prognostic factors only partially...
- Pediatric Diffuse Midline Gliomas: An Unfinished Puzzle - PMC
1 Ιουν 2023 · Diffuse midline glioma (DMG) is the leading cause of brain tumor-related deaths in children. DMG typically presents with variable neurologic symptoms between ages 3 and 10. Currently, radiation remains the standard therapy for DMG to halt progression and reduce tumor bulk to minimize symptoms.
16 Απρ 2024 · Conventionally fractionated radiation therapy to a total dose of 54-60 Gy in 27-30 fractions and 24 Gy in 12 fractions play a crucial role in the definitive treatment of these tumors in the primary and salvage settings, respectively.
21 Ιουν 2024 · Apatinib plus temozolomide could be an effective regimen with manageable toxicities and favorable efficacy and may outperform temozolomide monotherapy, particularly in newly diagnosed adults with tumors located outside the pons. The novel therapy deserves further investigation in adult DMG patients. Key points.
3 Νοε 2023 · Treatment. The standard therapy for newly diagnosed DMG patients is focal conventional fractionated radiation therapy in non-metastatic cases, with a total dose of 54–60 Gy administered over 6 weeks.
As a result, diffuse midline gliomas may sometimes be treated using radiation therapy alone without a biopsy if the risk of biopsy is too high. If the patient has hydrocephalus, a procedure (such as a ventriculoperitoneal shunt) may also be needed to redirect the flow of CSF.
Clinical and radiological prognostic factors only partially change the progression-free survival but they do not improve the overall survival. Despite efforts, there is currently no curative therapy for DMG. Radiotherapy remains the standard treatment with only transitory benefits.
