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Efficacy: DMSA 30 mg/kg/day significantly increases urine lead elimination and significantly reduces blood lead concentrations in lead-poisoned patients, though there is substantial individual variation in response.
- Management of Lead Encephalopathy with DMSA After Exposure to Lead ...
DMSA is an oral chelating agent that was originally...
- Use of oral dimercaptosuccinic acid (succimer) in adult ... - PubMed
DMSA caused a significant increase in urine copper (P <...
- Management of Lead Encephalopathy with DMSA After Exposure to Lead ...
DMSA is an oral chelating agent that was originally FDA-approved for treatment of lead toxicity in children with whole blood concentrations over 45 μg/dL . DMSA is a stable water-soluble derivative of dimercaprol (BAL) that chelates lead, iron, mercury, zinc, nickel, arsenic, and cadmium [ 8 ].
20 Αυγ 2009 · We report the largest case series of adult lead poisoned patients treated with DMSA 30 mg/kg/day in which comprehensive urine and blood data have been collected. The effect of chelation on urine lead excretion was the main outcome measure investigated, as this is the only easily measured parameter that can confirm a reduced body burden of lead.
6 Αυγ 2015 · DMSA is an oral chelating agent that was originally FDA-approved for treatment of lead toxicity in children with whole blood concentrations over 45 μg/dL . DMSA is a stable water-soluble derivative of dimercaprol (BAL) that chelates lead, iron, mercury, zinc, nickel, arsenic, and cadmium [ 8 ].
1 Ιουλ 2019 · Combined treatment of DMSA with α-lipoic acid in lead poising was found to improve oxidative damage [97, 98]. Additionally, CaNa 2 EDTA in combination with zinc showed improved chelating ability. Zinc and Selenium have shown protective potential against non-essential metals [ 39 , 99 , 100 ].
3 Νοε 2020 · Succimer (DMSA) is an orally active metal chelator is used to treat heavy metal poisoning. In adults Succimer is used for symptomatic lead poisoning or in patients who are asymptomatic with levels >60 micrograms/dL (>2.9 micro mol/L).
DMSA caused a significant increase in urine copper (P < 0.0001) and zinc (P < 0.05) excretion. Conclusion: Oral DMSA 30 mg/kg/day is an effective antidote for lead poisoning, though there is a wide inter- and intra-individual variation in response.
