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Define pharmacodynamics. Clarify how drugs alter neurotransmission. Contrast direct and indirect agonists and antagonists. Clarify the relationship between dose and effect. List and describe key values of note on dose-response curves. Explain how we measure drug safety. 6.1. Mechanisms of Drug Action. Section Learning Objectives.
Optimal doses of psychotherapy in routine settings range between 4 and 26 sessions (4-6 for low intensity guided self-help) and vary according to setting, clinical population and outcome measures. Weekly therapy appears to accelerate the rate of improvement compared to less frequent schedules.
How effective a dose is and what type of response it can have in a patient varies based on the route of administration, the absorption, the distribution in the body, and the clearance from the blood or site of action.
Psychological dependence, or drug craving, is a recent addition to the diagnostic criteria for substance use disorder in DSM-5. This is an important factor because we can develop tolerance and experience withdrawal from any number of drugs that we do not abuse.