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15 Φεβ 2024 · The atypical lymphocytes, or Downey cells, are larger CD8+ cytotoxic T cells adherent around erythrocytes, supporting the diagnosis. Possible differential diagnoses include other infectious causes such as TORCH infections, hepatitis B, syphilis, HIV, and SARS-CoV-2, as well as non-infectious conditions like autoimmune disorders, Hodgkin’s ...
- Infectious mononucleosis - American Society of Hematology
The variant lymphocyte in the centre has a classical so...
- Infectious mononucleosis - American Society of Hematology
During infectious mononucleosis when there are very high numbers of circulating CD8 T cells, many of these cells are EBV specific and directed toward lytically expressed proteins from the immediate early and early stages of the lytic cycle with particular predilection for the immediate early.
Clinical Picture. Infectious mononucleosis diagnosed by Downey cells: sometimes the old ways are better. Henry M Feder Jr, William N Rezuke. An 18-year-old woman visited her physician because she had a fever, a sore throat, and painful swellings in her neck for the past 5 days.
18 Ιαν 2020 · In 1923, McKinlay and Downey published a description of three types of reactive or atypical lymphocytes, which they called Downey cells. The presence of many of these cells became the standard laboratory test for infectious mononucleosis.
14 Σεπ 2017 · The variant lymphocyte in the centre has a classical so called “Ballerina skirt” appearance with scalloped margins and indentations by the surrounding red blood cells. The cytoplasm is vacuolated. Further testing demonstrated positive monospot test confirming Infectious mononucleosis.
1 Μαρ 2010 · A classical Downey cell is shown with abundant muddy basophilic cytoplasm and vacuolization.
18 Ιαν 2020 · Infectious mononucleosis diagnosed by Downey cells: sometimes the old ways are better. Lancet. 2020 Jan 18;395 (10219):225. doi: 10.1016/S0140-6736 (19)32962-9. Authors. Henry M Feder Jr 1 , William N Rezuke 2. Affiliations.
