Αποτελέσματα Αναζήτησης
8 Αυγ 2022 · The common fruit fly Drosophila melanogaster presents a valuable tool for screening and testing anticancer drugs in the preclinical stages of drug discovery. Drosophila present a high conservation of key genes, a low genetic redundancy, easy genetic manipulation and a rapid life cycle.
3 Ιαν 2024 · Recent sequencing efforts have unveiled the widespread presence of cells—often organised as clones—carrying canonical cancer mutations within our tissues such as TP53, FAT1 and NOTCH1....
25 Αυγ 2022 · The discovery of important genes regulating cell polarity in Drosophila makes it possible to establish fly cancer models with loss of such regulators to unravel metabolic reprogramming in tumor cells that had lost their polarity (125, 127, 129, 163).
28 Φεβ 2019 · Cancer Modeling in Drosophila. Most of the signaling pathways controlling cell growth and invasion in mammals have a conserved function in flies allowing their modulation into models that mimic tumor's biology in a simple model organism like Drosophila (Millburn et al., 2016).
13 Αυγ 2021 · From the isolation of tumour viruses to the discovery of oncogenes and tumour suppressor genes to contemporary cancer genomics, we now have a detailed understanding of the genetic, epigenetic...
21 Μαρ 2021 · Tumor models and related genes and pathways in different larval and adult tissues. (a) Larval tumor models in the brain, salivary gland imaginal ring, imaginal discs and hemocytes. (b) Adult tumor models in the gut, ovary, and testis. Tumor transplantation (xenograt) studies in Drosophila.
14 Σεπ 2019 · In this chapter we provide a historical overview of Drosophila as a model organism for cancer research, summarize the multitude of genetic tools available, offer a brief comparison between different model organisms and cell culture platforms used in cancer studies and briefly discuss some of the latest models and concepts in recent Drosophila ...
