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  1. 28 Ιουλ 2012 · The primary objective of this study was to assess the effects of citicoline compared with placebo on the recovery of patients with moderate-to-severe acute ischaemic stroke at 3 months, after having received 2000 mg daily for 6 weeks.

  2. Several studies have suggested that citicoline is effective in treatment of central nervous system disorders (CNS), including acute and chronic cerebral ischemia, intracerebral hemorrhage, global cerebral hypoxia, and neurodegenerative diseases (Martynov 2015).

  3. Recent research in animal models has suggested that neuroprotectant drugs can enhance repair and endogenous brain plasticity, reducing acute brain damage and improving functional recovery after an acute ischemic stroke [5, 6]. Citicoline is one such neuroprotectant drug.

  4. 15 Μαρ 2016 · Citicoline is a drug approved for the treatment of acute ischemic stroke. Although evidence of its efficacy has been reported, recently published results of a large placebo-controlled clinical trial did not show differences.

  5. This study aims to assess whether starting citicoline treatment within 14 days after stroke onset improves the outcome in patients with acute ischemic stroke, as compared with placebo.

  6. 29 Αυγ 2020 · This review assessed the benefits and harms of citicoline for treating patients with acute ischemic stroke. Objectives: To assess the clinical benefits and harms of citicoline compared with placebo or any other control for treating people with acute ischemic stroke.

  7. 12 Ιουλ 2022 · Conclusions: The eight-week treatment with citicoline after acute ischemic stroke may restore intracortical excitability measures, which partially depends on cholinergic transmission. This study extends current knowledge of the application of citicoline in acute ischemic stroke.

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