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This systematic review (SR) addresses the efficacy, comparative effectiveness, and harms of commonly used types of nonpharmacological and pharmacological treatments for childhood depression.
In this meta-review assessing the efficacy, tolerability and risk of suicidality of antidepressants across a number of psychiatric disorders in children and adolescents, we found evidence that, compared to placebo: (1) only fluoxetine was more efficacious, with a moderate effect but a large confidence interval, in decreasing the severity of ...
Comparative efficacy, acceptability, and safety of medicinal, cognitive-behavioral therapy, and placebo treatments for acute major depressive disorder in children and adolescents: a multiple-treatments meta-analysis.
24 Μαΐ 2021 · Objectives: To investigate, via network meta-analysis (NMA), the comparative effectiveness and safety of different newer generation antidepressants in children and adolescents with a diagnosed major depressive disorder (MDD) in terms of depression, functioning, suicide-related outcomes and other adverse outcomes.
3 Μαρ 2017 · The NIMH-funded trials, taken together with the demonstrated efficacy of the serotonin reuptake inhibitors for childhood-onset obsessive-compulsive disorder and the anxiety disorders, suggest a broad and important role for antidepressant medications in pediatric internalizing conditions.
Despite access to several nonpharmacological, pharmacological, and combined treatment options for childhood depression, clinicians contend with sparse evidence and are concerned about harms associated with treatment.
Serotonin Uptake Inhibitors. Fluoxetine. Despite an increasing number of studies, there is debate whether antidepressants have a favorable benefit/risk balance in depressed youth. Areas covered: A systematic search identified 23 systematic reviews and meta-analyses published between 2010-2016.
