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29 Ιουλ 2024 · Many common medications affect thermoregulation, the process by which your body maintains a healthy temperature. Some of these medications, including antihistamines and diuretics, may make it difficult to stay cool on extremely hot days.
1 Μαΐ 2024 · A 2020 PLOS ONE study found that various commonly prescribed drugs interfere with the body’s ability to perceive and protect itself from heat, increasing the risk of hospitalization.
The most commonly used drugs that affect thermoregulation include antipsychotic drugs, serotonergic drugs (especially when taken in combination), sympathomimetic drugs, anaesthetics and drugs with anticholinergic properties .
14 Νοε 2014 · In most cases, hyperthermic agents raise body temperature by increasing the central and peripheral release of thermoregulatory neurotransmitters that ultimately lead to heat production in thermogenic effector organs skeletal muscle (SKM) and brown adipose tissue (BAT).
Commonly used medicines that may significantly increase the risk include diuretics, especially when combined with an angiotensin converting enzyme (ACE) inhibitor or an angiotensin II receptor blocker (ARB), anticholinergics and psychotropics.
12 Ιουλ 2022 · Antipyretic drugs mainly affect body temperature by lowering the thermal setpoint and are reliant on a functioning thermoregulatory centre to have an effect.62 Physical cooling does not affect the thermoregulatory centre and acts by removing heat from the body without affecting the hypothalamic setpoint; the cooling is thus forced on the body ...
Randomised studies exposing humans to exertional and/or passive heat stress that investigated a drug identified by WHO compared to no drug/placebo were eligible. The primary outcome was core temperature (e.g., rectal, oesophageal, aural, tympanic). We assessed risk of bias (Cochrane’s Risk of Bias 2) and certainty of evidence (GRADE).
