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Elastic fibers provide reversible elasticity to the large, elastic arteries. This allows the aorta to deform elastically under an applied hemodynamic load, with no permanent deformation and no energy dissipation when the load is removed.
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We present mouse models of supravalvular aortic stenosis,...
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26 Δεκ 2019 · Top, the typical nonlinear relation between luminal pressure and area in large elastic arteries, explained by the progressive shift in load bearing from elastin to collagen fibers. Data translate into distensibility and pulse wave velocity (PWV) with the use of the Bramwell-Hill relation.
4 Μαΐ 2021 · An arterial wall has both elastic and viscous characteristics, and pathological and degenerative changes in the wall tissue affect the viscoelastic behavior of the artery wall. The arterial viscoelasticity may provide useful information regarding the development and progression of arterial diseases.
2 Φεβ 2018 · We present mouse models of supravalvular aortic stenosis, autosomal dominant cutis laxa-1, and graded elastin amounts that have been invaluable for understanding the role of elastin in arterial mechanics and cardiovascular disease.
20 Δεκ 2021 · Elastin is a long-lived extracellular matrix protein that is organized into elastic fibers that provide elasticity to the arterial wall, allowing stretch and recoil with each cardiac cycle. By forming lamellar units with smooth muscle cells, elastic fibers transduce tissue-level mechanics to cell-level changes through mechanobiological signaling.
the elastic properties, particularly of large arteries, are impaired in the presence of cardiovascular disease and risk factors such as cigarette smoking, hypertension, diabetes and ageing. Evidence is also emerging that treatment of these risk factors
Elasticity in Arteries: A similar combination of rubbery and stiff materials creates common mechanical properties in blood vessels of vertebrates and some invertebrates.
