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26 Οκτ 2021 · Ex vivo gene therapy involves removing blood, bone marrow or other tissues from a patient, isolating the cells of interest and correcting them in the lab before reinfusing them back into the...
This review will summarize the advent and clinical translation of ex vivo gene therapy, with the focus on the milestones during the exploitation of genetically engineered hematopoietic stem cells (HSCs) tackling a variety of pathological conditions which led to marketing approval.
12 Ιαν 2018 · Targeting organs in vivo is very attractive because it avoids the practical and regulatory hurdles of ex vivo cell-based gene therapies, which require cell collection, culture, and manipulation and transplantion.
29 Μαρ 2011 · Ex vivo cell therapies are based on the ability to isolate stem, progenitor or differentiated cells from a patient or a normal donor, expand them ex vivo — with or without genetic...
8 Νοε 2023 · Approaches include ex vivo modification of hematologic stem cells (HSC), T lymphocytes and other immune cells, as well as in vivo delivery of genes or gene editing reagents to the relevant...
In ex vivo gene therapy, the target cells are removed from the patient's body, engineered either by the addition of the therapeutic gene or by other genetic manipulations that allow correction of the phenotype of the disease. The “corrected” cells are subsequently re-infused to the patient.
1 Νοε 2021 · The Definition of Gene Therapy Has Changed. Over the past few years, the discipline has evolved in significant ways. By Esther Landhuis. Luisa Jung. November 2021 Issue. Medicine. Three decades...
