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7 Φεβ 2020 · During cell division, the distribution of membrane-bound organelles needs to be tightly regulated to ensure the proper composition and function of daughter cells.
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17 Οκτ 2019 · These examples suggest how several regulatory platforms may function in concert to control condensate assembly and properties. Regulatory input at multiple, independent levels may help provide robust control over the material states and identities of biomolecular condensates.
28 Ιαν 2021 · An example of a biomolecular condensate is a stress granule, which assembles in stressed cells from RNA and RNA-binding proteins (RBPs) in the cytosol, and has been linked to the regulation...
Here, we present a broad overview of recent approaches that take a comprehensive and “-omics” view to identify novel components critical for cell division, to understand the function of the cell division machinery, and to analyze the pathways and other novel factors that contribute to cell division.
These examples demonstrate how condensates can provide a physical means of maintaining cellular structures in proximity, such as neurotransmitter vesicles and VGCCs in the AZ condensate, as well as a mechanism for controlling the size of cellular structures, as postulated for Homer1a (Figure 3B).
18 Νοε 2019 · We propose two active mechanisms that can explain how cells regulate condensate formation and size. In both, the cell regulates the activity of an enzyme, often a kinase, that adds post-translational modifications to condensate proteins.
9 Νοε 2020 · In this Roadmap, we discuss representative examples of biochemical and cellular functions of biomolecular condensates from the recent literature and organize these functions into a series of...
