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  1. 11 Αυγ 2021 · Stressful lifestyle associated mutation (SLAM) experiments show that the adaptive mutation frequencies are 20 (S. cerevisiae -5-FC), 600 (C. albicans -5-FC) or 1000 (S. cerevisiae--CSP) fold...

  2. 27 Ιαν 2006 · A mutation is a heritable change in the genetic material that is not due to genetic recombination. Mutation alters the structure or number of genes or entire chromosomes. Keywords: evolution ...

  3. 23 Ιουν 2021 · Despite years of active research into the role of DNA repair and replication in mutagenesis, surprisingly little is known about the origin of spontaneous human mutation in the germ line. With...

  4. 6 Ιαν 2021 · This study analyses the evolution of somatic mutational processes and reconstructs the life history of 38 different types of cancer based on whole-genome sequences from 2,658 tumours.

  5. 23 Ιουν 2021 · human mutations have provided a new perspective on mutagenesis research. Here, we review statistical patterns in de novo germline mutations from parent–offspring trio sequenc-

  6. 1 Απρ 2019 · Abstract and Figures. Mutations drive evolution and were assumed to occur by chance: constantly, gradually, roughly uniformly in genomes, and without regard to environmental inputs, but this view...

  7. Genes that show high mutation rates contribute disproportionately to human disease. The highest mutation rates (m) for genes causing human disease are estimated to be in the region of 5–10 per 100000 gametes per generation. Examples include the poly-cystic kidney disease 1(PKD1)gene, the most common

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