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Typically this bleeding disorder manifests itself as a tendency to easy bruising, nose bleeding, heavy and prolonged menstruation, and excessive bleeding after dental or surgical interventions. Newborns may bleed in the head, from the umbilicus, or excessively after circumcision.
People with severe FVII deficiency experience joint and muscle bleeds, easy bruising and bleeds after surgery. Bleeds can also occur in the skin, mouth, nose and genitourinary tract. Women often experience severe menorrhagia, long, heavy periods.
Factor VII deficiency is the most common among rare inherited autosomal recessive bleeding disorders, and is a chameleon disease due to the lack of a direct correlation between plasma levels of coagulation Factor VII and bleeding manifestations.
9 Μαΐ 2023 · Factor VII deficiency is a rare genetic bleeding disorder characterized by a deficiency or reduced activity of clotting factor VII. Clotting factors are specialized proteins that are essential for the blood to clot normally.
Factor VII deficiency commonly causes nosebleeds (epistaxis), bleeding of the gums, easy bruising, and prolonged or excessive bleeding following surgery or physical injury. Bleeding into joint spaces (hemarthrosis) and blood in the urine (hematuria) occasionally occur.
28 Μαΐ 2023 · The symptoms of factor VII deficiency can vary depending on the severity of the disease. These are its common symptoms: Frequent bruising Bleeding in soft tissues and muscles
