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15 Μαΐ 2024 · Factor VII deficiency can lead to prolonged bleeding and easy bruising. Signs and symptoms include: Bleeding gums. Nosebleeds (epistaxis) that are hard to stop. Heavy periods (menorrhagia). Bloody pee (hematuria) or bloody stools. Ongoing bleeding after an injury, surgical procedure or childbirth.
Typically this bleeding disorder manifests itself as a tendency to easy bruising, nose bleeding, heavy and prolonged menstruation, and excessive bleeding after dental or surgical interventions. Newborns may bleed in the head, from the umbilicus, or excessively after circumcision.
Factor VII deficiency is the most common among rare inherited autosomal recessive bleeding disorders, and is a chameleon disease due to the lack of a direct correlation between plasma levels of coagulation Factor VII and bleeding manifestations.
Factor VII deficiency commonly causes nosebleeds (epistaxis), bleeding of the gums, easy bruising, and prolonged or excessive bleeding following surgery or physical injury. Bleeding into joint spaces (hemarthrosis) and blood in the urine (hematuria) occasionally occur.
28 Μαΐ 2023 · Factor VII deficiency can result in excessive bleeding due to a wound or surgery. Here is all you need to know about factor VII deficiency, along with its causes, symptoms, and treatments.
9 Μαΐ 2023 · Causes. Factor VII deficiency is caused by mutations of the F7 gene. These mutations are inherited in an autosomal recessive manner. Genetic diseases are determined by the combination of genes for a particular trait that are received from the father and the mother.
People with severe FVII deficiency experience joint and muscle bleeds, easy bruising and bleeds after surgery. Bleeds can also occur in the skin, mouth, nose and genitourinary tract. Women often experience severe menorrhagia, long, heavy periods.
