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15 Μαΐ 2024 · Factor VII deficiency can lead to prolonged bleeding and easy bruising. Signs and symptoms include: Bleeding gums. Nosebleeds (epistaxis) that are hard to stop. Heavy periods (menorrhagia). Bloody pee (hematuria) or bloody stools. Ongoing bleeding after an injury, surgical procedure or childbirth.
Several therapeutic options are currently available for the treatment of inherited FVII deficiency: i. recombinant activated Factor VII, ii. plasma-derived Factor VII, iii. fresh frozen plasma and iv. prothrombin complex concentrates.
The main treatment for FVII deficiency is recombinant factor VIIa (rFVIIa). Prothrombin complex concentrates (PCCs) can also be used, but the amount of factor VII they contain can vary considerably. Fresh frozen plasma (FFP) is another option. In some patients, the use of FFP has led to blood clots.
9 Μαΐ 2023 · Specific treatment options for acute bleeds in individuals with factor VII deficiency include recombinant factor VII, prothrombin complex concentrates, and fresh frozen plasma. Antifibrinolytics such as aminocaproic acid can help alleviate the bleeding symptoms.
3 Οκτ 2016 · These nonsevere manifestations in FVII deficiency mimic that of a platelet disorder and usually do not require any treatment. In the latter, extensive bruising and hemarthrosis are frequent (19% for both of them), gastrointestinal (GI) bleeding is relatively frequent (15%), whereas central nervous system (CNS) bleeding is less frequent (2.5% ...
28 Μαΐ 2023 · Factor VII deficiency can be treated using these clotting agents, which promote blood clotting and prevent bleeding: Recombinant factor VIIa. This is a replacement therapy to help...
29 Μαρ 2020 · Therapeutic options for treatment of FVII deficiency may include recombinant coagulation factor VIIa (FVIIa), fresh frozen plasma (FFP), prothrombin complex concentrates (PCC), and antifibrinolytic therapies.
