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Management of fibrosing mediastinitis. Specialists at Mayo Clinic have used off-label rituximab to treat nearly 30 patients with fibrosing mediastinitis successfully. Disease progression was almost universally halted and two-thirds of the patients improved symptomatically.
Fibrosing mediastinitis (FM), which is also known as mediastinal fibrosis or sclerosing mediastinitis, is an uncommon, benign and progressive condition characterized by an invasive proliferation of fibrous tissue within the mediastinum.
20 Αυγ 2021 · Medical treatments can help address some of the symptoms and complications caused by fibrosing mediastinitis. When fluid retention occurs related to vascular obstructions, patients are treated with diuretic therapy.
14 Δεκ 2019 · In patients with significant vascular occlusion with hemodynamic compromise, both stenting and surgical intervention (bypassing the occlusion) may be required to treat the vascular occlusion. Endovascular therapy is a safe and feasible treatment option with an acceptable safety profile with a high level of technical success .
27 Μαρ 2024 · The etiology, clinical presentation, diagnosis, treatment, and outcome of mediastinal granuloma and fibrosing mediastinitis are reviewed here. The presentation and treatment of pulmonary histoplasmosis and the approach to mediastinal masses are discussed separately.
12 Μαΐ 2018 · Although rare, fibrosing mediastinitis is an insidious complication of pulmonary histoplasmosis that must be recognized quickly, along with rapid stabilization and carefully crafted treatment plan. Medical therapy with antifungals and corticosteroids is not recommended routinely.
Although the definitive treatment of FM is unclear, the treatment should be symptomatic in the setting of uncertain etiology with close follow up.
