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Oral exposure to propylene glycol occurs through ingestion of foods, since propylene glycol is approved for use as a food additive. Ingestion by humans is not frequently associated with adverse effects.
Propylene glycol is a Generally Recognized as Safe (GRAS) food additive that is widely used in food and tobacco products, pharmaceuticals, and cosmetics. The most important routes of exposure to propylene glycol for members of the general population are ingestion and dermal contact with products containing this compound.
Ethylene glycol is a potent cause of acute toxicity in humans. In contrast, propylene glycol is a “generally recognized as safe” additive for foods and medications. Most reported cases of propylene glycol toxicity have resulted from propylene glycol used as a diluent for intravenous administration of benzodiazepines (Kraut and Kurtz 2008).
The ATSDR toxicological profile succinctly characterizes the toxicology and adverse health effects information for the toxic substance described therein. Each peer-reviewed profile identifies and reviews the key literature that describes a substance's toxicological properties.
17 Ιαν 2018 · Poisonings by the toxic alcohols (methanol, ethylene glycol, isopropanol, diethylene glycol, and propylene glycol) can cause cellular dysfunction and death, 1 but symptoms may be...
1 Απρ 2024 · The use of propylene glycol (PG) in food and other applications is widespread, and some estimates of dietary exposure to PG approach or exceed the Acceptable Daily Intake (ADI) of 25 mg/kg bw-day. The current ADI for PG applies a cumulative uncertainty factor of 100, which includes factors of 10 for both interspecies and intraspecies differences.
How Can People Reduce Their Risk for Ethylene Glycol Poisoning? What Tests Can Show if Someone Has Been Exposed to Ethylene Glycol? When to Call Your Doctor; Clinical Follow-up Instructions; Propylene Glycol Poisoning; Overview of Propylene Glycol; How Might I Be Exposed to Propylene Glycol ? How Can Propylene Glycol Affect My Health?
