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In patients with signs and symptoms indicative of hypogonadism, determining luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels together with the initial testosterone level is usually most efficient.
Total (and, when possible, free) serum testosterone, serum FSH, and serum LH levels are measured simultaneously. The normal range for total testosterone is 300 to 1000 ng/dL (10.5 to 35 nmol/L). The testosterone level should be drawn in the morning (before 10:00 AM) to confirm hypogonadism.
Additional investigations include measurement of gonadotrophins and prolactin, and the calculation of free testosterone when total testosterone is borderline and/or SHBG levels are unusually high or low. Methods for the calculation of free testosterone can be found at www.issam.ch.
Elevated LH and FSH values indicate primary (testicular) hypogonadism, whereas low or importantly even inappropriately ‘normal’ LH and FSH values may indicate secondary (pituitary–hypothalamic) hypogonadism.
In this study, most men above the age of 40 years experienced the symptoms of hypogonadism and the majority of the symptoms were related to psychological domain. The score of the symptoms in this domain had no association with serum levels of total and free testosterone.
Objective: Elevated luteinizing hormone (LH) with normal testosterone (T) suggests compensated dysregulation of the gonadal axis. We describe the natural history, risk factors and clinical parameters associated with the development of high LH (HLH, LH >9.4 U/L) in ageing men with normal T (T ≥ 10.5 nmol/L).
23 Νοε 2023 · Diagnosing imbalances in Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH) is a critical step in addressing the complex issues related to male hormonal health. The process involves a combination of clinical assessments, detailed medical histories, and specific laboratory tests.
