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Furosemide has a steep dose-effect curve, and therapeutic doses range from 40 to 200 mg daily in adults (Weiner & Mudge, 1985). Treatment of oedema is usually started with an initial oral dose of 40 mg daily; in severe cases, a gradual increase up to 600 mg daily may be required.
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The volume of distribution following intravenous administration of 40 mg furosemide were 0.181 L/kg in healthy subjects and 0.140 L/kg in patients with heart failure. 6 Protein binding Plasma concentrations ranging from 1 to 400 mcg/mL are about 91-99% bound in healthy individuals.
