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There are two major biologically distinct molecular subtypes of DLBCL: germinal center B-cell (GCB) and activated B-cell (ABC). ABC DLBCL is associated with substantially worse outcomes when treated with standard chemoimmunotherapy.
11 Απρ 2018 · The ABC–GCB predictor score is a quantitative metric used to assign DLBCL cases to the indicated gene-expression subgroups. High values (blue) are on the ABC end of the spectrum, and low...
Gene expression profiling (GEP) of DLBCL resulted in the identification of two major and clinically distinct subtypes that are classified based on cell of origin (COO) and are associated with differences in clinical outcome: GCB and non-GCB, which is further comprised of ABC and primary mediastinal B-cell types. 10,11 DLBCL subtypes have ...
3 Μαρ 2021 · Gene expression profiling has delineated two distinct molecular subtypes of DLBCL, the germinal center B-cell–like (GCB) subtype and the activated B-cell–like (ABC) subtype; 10 to 15% of cases...
30 Απρ 2018 · The genetically distinct COO subtypes (C1 and C5 ABC-DLBCLs; C3 and C4 GCB-DLBCLs) had marked differences in PFS and OS, with more favorable outcomes occuring in the newly defined C1 ABC- and...
Diffuse large B cell lymphoma (DLBCL), the most common lymphoid malignancy in adults, is a clinically and genetically heterogeneous disease that is further classified into transcriptionally defined activated B cell (ABC) and germinal center B cell (GCB) subtypes.
1 Νοε 2022 · The 2016 update of the World Health Organization (WHO) classification divides DLBCL, NOS into two subtypes based on cell of origin (COO): germinal center B cell like (GCB) and activated B cell like (ABC) (approximately 10-15% of cases remain unclassified) [5].
