Αποτελέσματα Αναζήτησης
11 Απρ 2018 · The ABC–GCB predictor score is a quantitative metric used to assign DLBCL cases to the indicated gene-expression subgroups. High values (blue) are on the ABC end of the spectrum, and low...
30 Απρ 2018 · The genetically distinct COO subtypes (C1 and C5 ABC-DLBCLs; C3 and C4 GCB-DLBCLs) had marked differences in PFS and OS, with more favorable outcomes occuring in the newly defined C1 ABC-...
Although patients with GCB DLBCL have better outcomes than patients with the ABC subtype, approximately 20% of patients with the GCB subtype of DLBCL relapse following R-CHOP or R-CHOP—like chemotherapy and DLBCL relapse is associated with poor outcomes regardless of molecular subtype.
20 Ιαν 2022 · Genomic analyses have immensely advanced our conception of the heterogeneity of diffuse large B cell lymphoma (DLBCL), resulting in subgroups with distinct molecular profiles. In this review, we summarize our current knowledge of the biology of DLBCL complexity and discuss the potential implications for precision medicine.
There are two major biologically distinct molecular subtypes of DLBCL: germinal center B-cell (GCB) and activated B-cell (ABC). ABC DLBCL is associated with substantially worse outcomes when treated with standard chemoimmunotherapy.
12 ώρες πριν · The system arrives close to sunset Friday and lingers into early Saturday morning. There is a chance some rain and snow will linger until noon, but the totals will be getting lighter. The storm ...
3 ημέρες πριν · Bruton’s tyrosine kinase inhibitors have been demonstrated preliminary efficacy in diffuse large B-cell lymphoma (DLBCL). To compare the safety and efficacy of zanubrutinib plus rituximab and lenalidomide (ZR2) and R-CHOP-like for elderly patients with newly diagnosed DLBCL, we conducted this single-center prospective study. Patients were treated with 6 cycles of ZR2 or R-CHOP-like regimen ...
