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11 Απρ 2018 · The ABC–GCB predictor score is a quantitative metric used to assign DLBCL cases to the indicated gene-expression subgroups. High values (blue) are on the ABC end of the spectrum, and low...
1 Σεπ 2009 · The 19 cases of CHOP-treated, GEP-unclassified DLBCL were assigned to either the GCB (7 cases) or ABC (12 cases) subtypes by the new algorithm. In comparison, the Hans' algorithm classified four cases into the “GCB” and 15 cases into the “non-GCB” subtypes.
1 Ιαν 2004 · Abstract. Diffuse large B-cell lymphoma (DLBCL) can be divided into prognostically important subgroups with germinal center B-cell–like (GCB), activated B-cell–like (ABC), and type 3 gene expression profiles using a cDNA microarray.
Outcomes are shown for historic control patients treated with R-CHOP and study patients treated with R2CHOP based on germinal center B-cell (GCB) versus non-GCB diffuse large B-cell lymphoma (DLBCL) subtype. (A) Progression-free survival in patients treated with R-CHOP for non-GCB versus GCB DLBCL.
There are two major biologically distinct molecular subtypes of DLBCL: germinal center B-cell (GCB) and activated B-cell (ABC). ABC DLBCL is associated with substantially worse outcomes when treated with standard chemoimmunotherapy.
2 Δεκ 2016 · Abstract. Introduction: The discovery of 3 distinct molecular subgroups of diffuse large B-cell lymphoma (DLBCL) according to cell-of-origin (COO): germinal centre B-cell (GCB), activated B-cell (ABC) and type III/unclassifiable by gene expression profiling (GEP) (Alizadeh et al, Nature 2000; Rosenwald et al, NEJM 2002) was a key advance in ...
19 Ιουν 2024 · A phase 2 expansion in patients with germinal-center B-cell (GCB) and non-GCB DLBCL was performed. ViPOR was administered every 21 days for six cycles.
