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Transcriptional activators are required to turn on the expression of genes in a eukaryotic cell. Activators bound to the enhancer can facilitate either the recruitment of RNA polymerase II to the promoter or its elongation. This article examines a ...
Gene activation and inactivation are complicated, multistep, and tightly controlled molecular mechanisms. Increasingly it is being recognized that the promoter CpG island of a silenced gene is occupied by a polycomb group complex that modulates chromatin remodeling.
Gene activation occurs when a stimulation, normally a physical-biological element, stimulates the natural proteins that are part of the genetic material of cells and is thus turning the genes “on” that were “off” and is therefore considered to be gene-regulating.
28 Φεβ 2021 · Just as the trp operon is negatively regulated by tryptophan molecules, there are proteins that bind to the operator sequences that act as a positive regulator to turn genes on and activate them. For example, when glucose is scarce, E. coli bacteria can turn to other sugar sources for fuel.
Gene activation (transactivation) is mediated by binding of the glucocorticoid-glucocorticoid receptor complex to a defined sequence in the promoter regions of the target genes, termed Glucocorticoid Responsive Elements (GRE) (Beato et al., 1989). From: Critical Reviews in Oncology/Hematology, 2018.
Because the active, DNA-binding form of such a protein turns genes on, this mode of gene regulation is called positive control, and the gene regulatory proteins that function in this manner are known as transcriptional activators or gene activator proteins. In some cases, bacterial gene activator proteins aid RNA polymerase in binding to the ...
