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Transcriptional activators are required to turn on the expression of genes in a eukaryotic cell. Activators bound to the enhancer can facilitate either the recruitment of RNA polymerase II to the promoter or its elongation.
Further examples of AP-1 bound activation hubs are observed at key macrophage regulatory genes including MAFB and IL1β (Fig. S6A–C). The gain of AP-1 enhancer-promoter interactions are in certain cases marked as well by CTCF binding, suggesting AP-1 binding may be directed towards gene promoters for gene activation by CTCF .
1 Introduction. Gene activation and inactivation are complicated, multistep, and tightly controlled molecular mechanisms. Increasingly it is being recognized that the promoter CpG island of a silenced gene is occupied by a polycomb group complex that modulates chromatin remodeling.
1 Ιαν 2014 · In contrast, the roles of ncRNAs in activating gene expression remains poorly understood. In this review, we summarize the current knowledge of gene activation by small RNAs, long non-coding RNAs, and enhancer-derived RNAs, with an emphasis on epigenetic mechanisms.
2 Απρ 2012 · Figure 1. (a) The context model of gene expression consists of three layers of regulation, each representing a level of interactions that allows the transition from code to context. (b) DNA, the first layer, interacts with non-coding RNA (arbitrary sequence in blue), TFs (green) and histone modifications (red).
Activation of gene expression requires that cells alleviate nucleosome-mediated repression of an appropriate subset of genes. This is accomplished by means of activator proteins that modify chromatin structure.
28 Νοε 2022 · An RNA-binding protein that can direct activators to endogenous introns would be an ideal system to achieve Narta. dCas13-VPR can activate gene expression by using a highly efficient crRNA...
