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Activation of gene expression requires that cells alleviate nucleosome-mediated repression of an appropriate subset of genes. This is accomplished by means of activator proteins that modify chromatin structure.
1 Ιαν 2016 · Therefore, many principles of eukaryotic gene regulation, such as the interaction with co-activator and co-repressor proteins, were first understood at the example of nuclear receptors.
The binding of the activators to the switches activates transcription. Some genes, especially genes involved in body development, have multiple switches. Each switch independently regulates the expression of the gene in different parts of the body at different times in the animal’s life cycle.
27 Απρ 2010 · We use three well‐characterized examples of induc‐ ible gene expression to illustrate some of the key mecha‐ nisms involved in transcription activation in response to stimuli: Gal gene...
Gene activation occurs when a stimulation, normally a physical-biological element, stimulates the natural proteins that are part of the genetic material of cells and is thus turning the genes “on” that were “off” and is therefore considered to be gene-regulating.
Gene Regulation in Prokaryotes. unwound and the polymerase is positioned to initiate transcription. This is followed by promoter escape, or clearance, the step in which polymerase leaves the promoter and starts transcribing. Which steps are stimulated by activators and inhibited by repressors?
we discuss the principles of STAT1-driven gene expression and focus on the clinical phenotypes of various human STAT1 mutations. In particular, we highlight the sig-nificance of sequence-specific DNA binding and intact nucleocytoplasmic shuttling for full transcriptional activation of interferon-driven target genes.
