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2 Μαρ 2016 · PDF | On Mar 2, 2016, Anca Botezatu and others published Mechanisms of Oncogene Activation | Find, read and cite all the research you need on ResearchGate
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PDF | On Mar 2, 2016, Anca Botezatu and others published...
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The activation of oncogenes involves genetic changes to cellular protooncogenes. The consequence of these genetic alterations is to confer a growth advantage to the cell. Three genetic mechanisms activate oncogenes in human neoplasms: (1) mutation, (2) gene amplification, and (3) chromosome rearrangements.
Activation of gene expression requires that cells alleviate nucleosome-mediated repression of an appropriate subset of genes. This is accomplished by means of activator proteins that modify chromatin structure.
3 Δεκ 2014 · Activation of oncogenes by structural alterations (chromosomal rearrangement, gene fusion, mutation, and gene amplification) or epigenetic modification (gene promoter hypomethylation) confers an increased or a deregulated expression.
Gene activation and inactivation are complicated, multistep, and tightly controlled molecular mechanisms. Increasingly it is being recognized that the promoter CpG island of a silenced gene is occupied by a polycomb group complex that modulates chromatin remodeling.
we discuss the principles of STAT1-driven gene expression and focus on the clinical phenotypes of various human STAT1 mutations. In particular, we highlight the sig-nificance of sequence-specific DNA binding and intact nucleocytoplasmic shuttling for full transcriptional activation of interferon-driven target genes.
Gene activation occurs when a stimulation, normally a physical-biological element, stimulates the natural proteins that are part of the genetic material of cells and is thus turning the genes “on” that were “off” and is therefore considered to be gene-regulating.
