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23 Σεπ 2021 · However, gene discovery studies for both forms of obesity show that they have shared genetic and biological underpinnings, pointing to a key role for the brain in the control of body weight.
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There is a clear sexual dimorphism in obesity prevalence, which can be explained by differences in obesity pathophysiology, including fat distribution, energy metabolism, and gut microbiota diversity, as well as the impact of chromosomes and genetic predisposition.
14 Σεπ 2017 · Gene by environment and lifestyle interaction analyses have revealed that our increasingly obesogenic environment might be amplifying genetic risk for obesity, yet those at highest risk could mitigate this risk by increasing physical activity and possibly by avoiding specific dietary components.
Despite environmental changes over the past decades, including increases in high-calorie foods and sedentary lifestyles, there is very clear evidence of a genetic predisposition to obesity risk. Childhood obesity cases can be categorized in one of two ways: syndromic or non-syndromic.
Genetic causes of obesity can be broadly classified into: Monogenic causes: those caused by a single gene mutation, primarily located in the leptin- melanocortin pathway. Syndromic obesity: severe obesity associated with other phenotypes such as neurodevelopmental abnormalities, and other organ/system malformations.
11 Οκτ 2023 · Enormous progress has been made in understanding the genetic architecture of obesity and the correlation of epigenetic marks with obesity and related traits. This review highlights current research and its challenges in genetics and epigenetics of obesity.
18 Μαΐ 2023 · Obesity arises when a mix of genetic and epigenetic factors, behavioural risk patterns and broader environmental and sociocultural influences affect the two body weight regulation systems:...
