Αποτελέσματα Αναζήτησης
5 Ιουν 2024 · In recent years, gene therapy has emerged as a promising means to address hereditary hearing loss, accelerated by recent advances in molecular biology, genetics and virology. AAVs have been...
14 Ιουν 2023 · Recent developments in the methods available for modifying and correcting genetic abnormalities, together with our increased understanding of the genes responsible for deafness, have meant that gene-based therapy has become an appealing approach for addressing hearing loss.
25 Μαΐ 2024 · In the single-arm trial by Lv and colleagues, 2 six patients (aged 1–6 years, three boys and three girls of Han ethnicity) with severe-to-complete autosomal recessive deafness 9-associated hearing loss received dual-AAV1-h OTOF vectors injected into the cochlea, through the round window.
24 Ιαν 2024 · A novel gene therapy approach has given five children who were born deaf the ability to hear. The method, which overcomes a roadblock presented by large genes, may be useful in other treatments, according to researchers.
16 Μαρ 2024 · At present, several clinical trials of gene therapy for hereditary deafness are underway. However, few normative documents have been issued to guide the standardization of gene therapy for hearing loss, and this document is the first global gene therapy guideline for hereditary hearing loss.
3 ημέρες πριν · Gene therapy clinical trials are underway for congenital hearing loss caused by variations in a specific gene known as the otoferlin gene (OTOF). Otoferlin is a protein in hair cells that helps convert sound into a signal that can be interpreted by the brain. Otoferlin gene variations cause 1 to 8% of congenital hearing loss cases.
4 Δεκ 2023 · Herein, we summarize the primary gene therapy strategies employed over past years, provide an overview of the recent achievements in preclinical studies for genetic hearing loss, and outline the current key obstacles to cochlear gene therapy.
