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5 Οκτ 2024 · This condition, described in the early 1900s by Gilbert, Castaigne, and Lereboulette, is an autosomal recessive disorder that is a frequent cause of mild-to-moderate isolated unconjugated hyperbilirubinemia. The prevalence of Gilbert syndrome ranges from 2% to 20%, depending on an individual's ethnicity. [1] [2] Reduced glucuronidation of ...
Gilbert’s syndrome manifests as mild unconjugated asymptomatic hyperbilirubinaemia, usually found in young adults during routine laboratory check-ups or after an intercurrent illness. The diagnosis is typically made per exclusionem, i.e. by excluding other causes of hyperbilirubinaemia.
Key learning points. Gilbert’s syndrome (GS) is the commonest hereditary unconjugated hyperbilirubinaemia. GS is a benign, self-resolving jaundice with otherwise normal liver function tests and absence of haemolysis. GS can coexist with other causes of unconjugated hyperbilirubinaemia, in particular hereditary spherocytosis/ thalassaemia.
6 Σεπ 2022 · Gilbert syndrome (GS) is a genetic syndrome of mild unconjugated hyperbilirubinaemia, by definition <102 micromol/L (<6 mg/dL) (rarely exceeding 68.4 micromol/L [4 mg/dL]). The liver function is otherwise normal. Common syndrome affecting approximately 6% of the general population.
Diagnoses can include conditions of disordered bilirubin metabolism (Gilbert's, Crigler-Najjar, Rotor, or Dubin-Johnson syndromes) or an acquired disease, including alcoholic/non-alcoholic fatty liver disease, hepatotropic hepatitis, cirrhosis, or hepato-biliary malignancy.
1 Φεβ 2018 · Mildly elevated total bilirubin with normal serum activities of liver transaminases, biliary damage markers, and red blood cell counts, however, may indicate the presence of Gilbert’s syndrome (GS), a benign condition that is present in ∼5–10% of the population.
Diagnosis and Treatment of Alcohol-Associated Liver Diseases: 2019 Practice Guidance From the American Association for the Study of Liver Diseases. Hepatology. 2020 Jan;71 (1):306-333. doi: 10.1002/hep.30866.
