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12 Ιουλ 2023 · Evidence from the analyses of genetic data suggests that bilirubin has no likely causal role in protection from cardiovascular disease, chronic obstructive pulmonary disease, or other key healthcare outcomes and therefore represents a poor target for therapeutic intervention for these outcomes.
causal role for bilirubin outside of biliary disease and pityriasis rosea ⇒ Clinicians should be aware of the increased rates of biliary pathology in people with Gilbert syndrome, while researchers should not prioritise
Gilbert’s syndrome manifests as mild unconjugated asymptomatic hyperbilirubinaemia, usually found in young adults during routine laboratory check-ups or after an intercurrent illness. The diagnosis is typically made per exclusionem, i.e. by excluding other causes of hyperbilirubinaemia.
5 Οκτ 2024 · Identify the clinical signs and triggers of mild unconjugated hyperbilirubinemia in patients with Gilbert syndrome. Differentiate Gilbert syndrome from other causes of jaundice and hyperbilirubinemia through clinical and laboratory assessment.
1 Οκτ 2023 · Due to the potent antioxidant and hormone-like effects of bilirubin, individuals with Gilbert's syndrome are protected from the “diseases of civilisation” such as cardiovascular diseases, certain cancers, and autoimmune or neurodegenerative diseases.
Abstract. Background and aims: Gilbert's syndrome is a common familial hyperbilirubinemia that may reduce the risk of various age-related diseases because of the antioxidant properties of bilirubin.
1 Φεβ 2018 · Diagnoses can include conditions of disordered bilirubin metabolism (Gilbert’s, Crigler-Najjar, Rotor, or Dubin-Johnson syndromes) or an acquired disease, including alcoholic/non-alcoholic fatty liver disease, hepatotropic hepatitis, cirrhosis, or hepato-biliary malignancy.
