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Gilbert’s syndrome manifests as mild unconjugated asymptomatic hyperbilirubinaemia, usually found in young adults during routine laboratory check-ups or after an intercurrent illness. The diagnosis is typically made per exclusionem, i.e. by excluding other causes of hyperbilirubinaemia.
5 Οκτ 2024 · This activity for healthcare professionals reviews the etiology, epidemiology, pathophysiology, clinical presentation, recommended evaluation, and management of Gilbert syndrome and highlights the role of the interprofessional team in improving the quality of life and outcomes for patients with this genetic disorder.
causal role for bilirubin outside of biliary disease and pityriasis rosea ⇒ Clinicians should be aware of the increased rates of biliary pathology in people with Gilbert syndrome, while researchers should not prioritise
Gilbert’s syndrome (MIM#143500) is a common form of unconjugated hyperbilirubinaemia caused by an inherited deficiency in the bilirubin-conjugating enzyme UDP-glucuronosyltransferase 1-1 (UGT1A1) [1].
28 Ιαν 2024 · Gilbert's syndrome (GS) is a benign, familial condition characterized by recurrent asymptomatic non-hemolytic low-grade indirect hyper-bilirubinemia.
The aim of this review is to understand the correlation between elevated bilirubin levels and the risk of developing selected diseases in individuals with Gilbert's syndrome and how to use...
12 Ιουλ 2023 · We defined genetic exposure in multiple ways. Firstly, we performed an additive model, defining exposure as the number of Gilbert syndrome risk alleles (rs887829-T). Secondly, we analysed people who had a Gilbert syndrome genotype (eg, homozygotes for rs887829-T).
