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Gilbert’s syndrome manifests as mild unconjugated asymptomatic hyperbilirubinaemia, usually found in young adults during routine laboratory check-ups or after an intercurrent illness. The diagnosis is typically made per exclusionem, i.e. by excluding other causes of hyperbilirubinaemia.
12 Ιουλ 2023 · Evidence from the analyses of genetic data suggests that bilirubin has no likely causal role in protection from cardiovascular disease, chronic obstructive pulmonary disease, or other key healthcare outcomes and therefore represents a poor target for therapeutic intervention for these outcomes.
causal role for bilirubin outside of biliary disease and pityriasis rosea ⇒ Clinicians should be aware of the increased rates of biliary pathology in people with Gilbert syndrome, while researchers should not prioritise
The aim of this review is to understand the correlation between elevated bilirubin levels and the risk of developing selected diseases in individuals with Gilbert's syndrome and how to use...
Background and aims: Gilbert's syndrome is a common familial hyperbilirubinemia that may reduce the risk of various age-related diseases because of the antioxidant properties of bilirubin. We conducted a large cohort study using The Health Improvement Network primary care database and compared all-cause mortality rates in those with and without ...
Key learning points. Gilbert’s syndrome (GS) is the commonest hereditary unconjugated hyperbilirubinaemia. GS is a benign, self-resolving jaundice with otherwise normal liver function tests and absence of haemolysis. GS can coexist with other causes of unconjugated hyperbilirubinaemia, in particular hereditary spherocytosis/ thalassaemia.
Introduction. Alcohol is a major cause of liver disease globally and may be a cause or co-factor in up to 80% of liver-related deaths in some countries [].There is however significant geographic variation in the rate of alcohol-associated liver disease (ALD) [].There is now evidence of a dose-response relationship between alcohol consumption and the risk of liver disease and several evidence ...
