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  1. Gilbert’s syndrome manifests as mild unconjugated asymptomatic hyperbilirubinaemia, usually found in young adults during routine laboratory check-ups or after an intercurrent illness. The diagnosis is typically made per exclusionem, i.e. by excluding other causes of hyperbilirubinaemia.

  2. causal role for bilirubin outside of biliary disease and pityriasis rosea ⇒ Clinicians should be aware of the increased rates of biliary pathology in people with Gilbert syndrome, while researchers should not prioritise

  3. 5 Οκτ 2024 · This condition, described in the early 1900s by Gilbert, Castaigne, and Lereboulette, is an autosomal recessive disorder that is a frequent cause of mild-to-moderate isolated unconjugated hyperbilirubinemia. The prevalence of Gilbert syndrome ranges from 2% to 20%, depending on an individual's ethnicity. [1] [2] Reduced glucuronidation of ...

  4. 12 Ιουλ 2023 · Odds ratios for the association between serum bilirubin concentrations, rs887829-T homozygosity (the risk genotype for Gilbert syndrome), genetically predicted bilirubin using rs887829-T allele carriage alone, and a wide range of health outcomes recorded in primary and secondary care.

  5. 12 Ιουλ 2023 · Evidence from the analyses of genetic data suggests that bilirubin has no likely causal role in protection from cardiovascular disease, chronic obstructive pulmonary disease, or other key healthcare outcomes and therefore represents a poor target for therapeutic intervention for these outcomes.

  6. 1 Οκτ 2023 · Due to the potent antioxidant and hormone-like effects of bilirubin, individuals with Gilbert's syndrome are protected from the “diseases of civilisation” such as cardiovascular diseases, certain cancers, and autoimmune or neurodegenerative diseases.

  7. We conducted a large cohort study using The Health Improvement Network primary care database and compared all-cause mortality rates in those with and without Gilbert's syndrome.

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