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5 Οκτ 2024 · Gilbert syndrome is a benign, inherited disorder of bilirubin metabolism without the risk of progressive liver disease, hepatic decompensation, or increased mortality. However, these patients are at increased risk from drug toxicity when exposed to medications that suppress or affect UGT1A1 activity.
Gilbert’s syndrome manifests as mild unconjugated asymptomatic hyperbilirubinaemia, usually found in young adults during routine laboratory check-ups or after an intercurrent illness. The diagnosis is typically made per exclusionem, i.e. by excluding other causes of hyperbilirubinaemia.
1 ημέρα πριν · Introduction. Liver disease that is related to heavy alcohol consumption is a significant global health issue [].Deaths linked to alcohol-associated liver disease (ALD) accounted for 25% of global cirrhosis deaths in 2019 [] and are predicted to increase [].Liver damage caused by alcohol use begins with hepatic steatosis that progresses histologically to steatohepatitis and fibrosis ...
23 Οκτ 2023 · Gilbert syndrome is an inherited disorder of the liver that results in an overabundance of a substance known as bilirubin. While some people with Gilbert syndrome develop yellowing of the skin or eyes, most people have no symptoms at all.
18 Σεπ 2018 · Alcohol can temporarily raise bilirubin levels in people with Gilbert’s syndrome. What causes it? Gilbert’s syndrome is a genetic condition that’s passed down from your parents.
1 Οκτ 2023 · An ‘iatrogenic’ increase of bilirubin (induced Gilbert's syndrome), e.g. using nanoparticles to deliver bilirubin to tissues and organs of interest, may be an option to treat inflammatory, metabolic, and oncological diseases.
6 Σεπ 2022 · Gilbert syndrome (GS) is a genetic syndrome of mild unconjugated hyperbilirubinaemia, by definition <102 micromol/L (<6 mg/dL) (rarely exceeding 68.4 micromol/L [4 mg/dL]). The liver function is otherwise normal. Common syndrome affecting approximately 6% of the general population.