Αποτελέσματα Αναζήτησης
9 Φεβ 2022 · A major rate-limiting step in developing more effective immunotherapies for GBM is our inadequate understanding of the cellular complexity and the molecular heterogeneity of immune infiltrates...
- Nature
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- A single-cell atlas of glioblastoma evolution under therapy reveals ...
We identified tumor-supportive networks of paracrine and...
- Multi-omics and pharmacological characterization of patient-derived ...
Glioblastoma (GBM) is the most common brain tumor and...
- Nature
20 Δεκ 2022 · We identified tumor-supportive networks of paracrine and autocrine signals between GBM cells, nonmalignant neuroglia and immune cells.
8 Ιουλ 2024 · We seek to expand the molecular landscape of high-grade glioma, composed of IDH-wildtype GBM and IDH-mutant grade 4 astrocytoma, by integrating proteomic, metabolomic, lipidomic, and post-translational modifications (PTMs) with genomic and transcriptomic measurements to uncover multi-scale regulatory interactions governing tumor development and ...
11 Φεβ 2021 · Glioblastoma (GBM) is the most aggressive nervous system cancer. Understanding its molecular pathogenesis is crucial to improving diagnosis and treatment. Integrated analysis of genomic, proteomic, post-translational modification and metabolomic data on 99 treatment-naive GBMs provides insights to GBM biology.
8 Αυγ 2024 · Glioblastoma (GBM) is the most common brain tumor and remains incurable. Primary GBM cultures are widely used tools for drug screening, but there is a lack of genomic and pharmacological...
11 Απρ 2022 · Genomic profiling reveals cellular variability of glioblastoma (GBM) model systems. •. Samples profiled include matched GBM tissues, explants, and gliomaspheres.
Abstract. Glioblastoma (GBM) is a particularly devastating tumor with a median survival of about 16 months. Recent research has revealed novel insights into the outstanding heterogeneity of this type of brain cancer. However, all GBM subtypes share the hallmark feature of aggressive invasion into the surrounding tissue.
