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Describe how FA synthesis is signaled to be initiated. At high blood glucose, Insulin goes up, signalling ACC (Acetyl-CoA) to be dephosphorylated via activated phosphatase. ACC then converts acetyl-CoA into malonyl CoA at which point it is destined to feed into the fatty acid synthesis pathway.
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Lipogenesis. When glucose levels are plentiful, the excess acetyl CoA generated by glycolysis can be converted into fatty acids, triglycerides, cholesterol, steroids, and bile salts. This process, called lipogenesis, creates lipids (fat) from the acetyl CoA and takes place in the cytoplasm of adipocytes (fat cells) and hepatocytes (liver cells ...
30 Ιουλ 2022 · Lipogenesis. When glucose levels are plentiful, the excess acetyl CoA generated by glycolysis can be converted into fatty acids, triglycerides, cholesterol, steroids, and bile salts. This process, called lipogenesis, creates lipids (fat) from the acetyl CoA and takes place in the cytoplasm of adipocytes (fat cells) and hepatocytes (liver cells ...
Below we discuss the different pathways involved in lipogenesis and how they are altered in metabolic diseases, particularly NAFLD and type 2 diabetes (T2DM). Figure 1.
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