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30 Ιουλ 2022 · Lipogenesis. When glucose levels are plentiful, the excess acetyl CoA generated by glycolysis can be converted into fatty acids, triglycerides, cholesterol, steroids, and bile salts. This process, called lipogenesis, creates lipids (fat) from the acetyl CoA and takes place in the cytoplasm of adipocytes (fat cells) and hepatocytes (liver cells ...
1 Απρ 2024 · Glucose-driven Golgi phosphatidylinositol 4-phosphate levels impact the assembly of E3 ligase complex CUL7–FBXW8, controlling adipose triglyceride lipase levels and lipolysis.
Compared to glucose (32 ATP) you can see that there is far more energy stored in a fatty acid. This is because fatty acids are in a more reduced form and thus, they yield 9 kcal/g instead of 4 kcal/g like carbohydrates5. The following animation reviews lipolysis and beta-oxidation.
Lipogenesis is a process that converts carbohydrates and other substrates into fatty acids, which are then stored as TAGs. Key enzymes involved in lipogenesis are exquisitely regulated by...
4 Μαΐ 2023 · The authors show that adipose de novo lipogenesis is supported by glucose, and the pentose phosphate pathway provides NADPH, while hepatic lipogenesis mainly uses acetate and lactate, with...
Below we discuss the different pathways involved in lipogenesis and how they are altered in metabolic diseases, particularly NAFLD and type 2 diabetes (T2DM). Figure 1. Open in a new tab
Glucose utilization in the pentose phosphate pathway and malic enzyme activity lead to NADPH+H + formation needed by fatty acid synthase (FAS). Insulin activates these pathways by stimulating glycolytic and lipogenic enzymes [ 88 , 89 ] and through its action on transcription factors as described below (c.f. Section 3.2 ) ( Fig. 4 ).
