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Lipogenesis is a process that converts carbohydrates and other substrates into fatty acids, which are then stored as TAGs. Key enzymes involved in lipogenesis are exquisitely regulated by...
1 Απρ 2024 · Glucose-driven Golgi phosphatidylinositol 4-phosphate levels impact the assembly of E3 ligase complex CUL7–FBXW8, controlling adipose triglyceride lipase levels and lipolysis.
4 Μαΐ 2023 · The authors show that adipose de novo lipogenesis is supported by glucose, and the pentose phosphate pathway provides NADPH, while hepatic lipogenesis mainly uses acetate and lactate, with...
4 Μαΐ 2023 · Here we show using stable isotope tracing in mice that de novo lipogenesis in adipose is supported by glucose and its catabolism via the pentose phosphate pathway to make NADPH.
Below we discuss the different pathways involved in lipogenesis and how they are altered in metabolic diseases, particularly NAFLD and type 2 diabetes (T2DM). Figure 1. Open in a new tab
1 Απρ 2021 · Glucose release from hepatocytes (and gut enterocytes) is represented by the balance between intracellular glucose-6-P synthesis from glycogenolysis, gluconeogenesis and glucose phosphorylation on one hand, and glucose-6-phosphate disposal into glycogen synthesis and glycolysis on the other hand.
The pathways and some critical enzymes involved in lipogenesis in adipose tissue from 82 patients have been studied. Of the glucose- 14 C metabolized to lipid by isolated adipose cells, approximately 0.6% was recovered in fatty acids and the rest in glyceride-glycerol.
