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30 Ιουλ 2022 · Lipogenesis. When glucose levels are plentiful, the excess acetyl CoA generated by glycolysis can be converted into fatty acids, triglycerides, cholesterol, steroids, and bile salts. This process, called lipogenesis, creates lipids (fat) from the acetyl CoA and takes place in the cytoplasm of adipocytes (fat cells) and hepatocytes (liver cells ...
4 Μαΐ 2023 · The authors show that adipose de novo lipogenesis is supported by glucose, and the pentose phosphate pathway provides NADPH, while hepatic lipogenesis mainly uses acetate and lactate, with...
Complex hormonal activators in lipogenesis. The contribution of glucocorticoids to lipogenesis is complex and depends on the hor-monal status. In the absence of insulin or fasting conditions ...
The interaction of glucose and lipogenic gene expression is assumed to be managed by the increasing concentration of an unknown glucose metabolite through the activity of glucokinase. Another hormone that may affect lipogenesis through the SREBP-1 pathway is leptin.
1 Απρ 2024 · In summary, our findings identify an intrinsic pathway that links glucose availability to lipid availability via glucose sensing by a Golgi PtdIns4P–ATGL–lipolysis pathway that...
Lipogenesis. When glucose levels are plentiful, the excess acetyl CoA generated by glycolysis can be converted into fatty acids, triglycerides, cholesterol, steroids, and bile salts. This process, called lipogenesis, creates lipids (fat) from the acetyl CoA and takes place in the cytoplasm of adipocytes (fat cells) and hepatocytes (liver cells ...
Below we discuss the different pathways involved in lipogenesis and how they are altered in metabolic diseases, particularly NAFLD and type 2 diabetes (T2DM). Figure 1.
