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20 Σεπ 2024 · Typically, a gout flare affects a single joint, although flares affecting multiple joints commonly occur. Without therapy, a gout flare usually resolves completely within a few days to several weeks, particularly in early disease. However, symptoms improve faster with treatment [1].
30 Νοε 2023 · Where 0.5 mg is the only available form, an initial dose of 1 mg may be used, followed by 0.5 mg one hour later for a total of 1.5 mg for the first day of therapy. Subsequently, the colchicine dose may be reduced to 0.5 mg twice daily until 48 hours after the resolution of the flare.
1 Ιαν 2005 · For the treatment of flare, colchicine, non-steroidal anti-inflammatory drugs (NSAIDs), oral or intra-articular steroids or a combination are recommended. In patients with frequent flare and contraindications to colchicine, NSAIDs and corticosteroids, an interleukin-1 blocker should be considered.
16 Νοε 2022 · •. When feasible, patients should keep medication on hand (the “pill-in-a-pocket” approach) to facilitate early antiinflammatory treatment of gout flares. •.
3 Φεβ 2022 · During phase 3, 36.5% of allopurinol-treated participants had one flare or more compared with 43.5% of febuxostat-treated participants (P<0.001 for noninferiority). Overall, 80% of participants...
15 Ιουν 2023 · The following recommendations were strongly recommended by two or more CPGs: Serum uric acid (sUA) levels should be monitored and ULT should be based on a treat-to-target strategy and adjusted to achieve a sUA target < 6 mg/dL (360 mmol/L) lifelong or sUA < 5 mg/dL (300mmol/L) for patients with severe or tophaceous gout [25, 29, 32] with one ...
Urate-lowering therapy is recommended for patients with two or more gout flare-ups per year, tophaceous gout, or damage attributable to gout visible on radiography.
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