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1 Απρ 2019 · The aim of this systematic literature review was to describe comprehensively the anatomical pathology of gout, including the macroscopic appearances, light microscopy (including immunohistochemistry) and electron microscopy.
- Peer Review Reports
The aim of this systematic literature review was to...
- Peer Review Reports
30 Νοε 2019 · Gout flares are marked by MSU crystals in synovial fluid obtained from affected joints of bursas, visualized through direct examination of a fluid sample using compensated polarized light microscopy. The crystals are often intracellular, indicating active phagocytosis.
The initial attack (flare) of gout is usually monarticular and often involves the 1st metatarsophalangeal joint. Symptoms of gout include acute, severe pain, tenderness, warmth, redness, and swelling. Definite diagnosis requires identification of crystals in synovial fluid.
1 Απρ 2019 · Consistent with the clinical presentation of gout, most studies describing the anatomical pathology of gout report involvement of musculoskeletal structures, with monosodium urate crystal deposition and tophus the most common lesions described.
1 Νοε 2020 · In this article, we discuss the mechanisms underlying the pathophysiologic checkpoints of gout (Fig. 1), including the development of hyperuricemia, MSU crystal deposition, the inflammatory response to MSU crystals, tophus formation, and structural joint damage. Download: Download high-res image (531KB) Download: Download full-size image. Figure 1.
24 Μαΐ 2024 · Gout is a disease that occurs in response to the presence of monosodium urate (MSU) crystals in joints, bones, and soft tissues. It may result in one or a combination of acute arthritis (a gout flare), chronic arthritis (chronic gouty arthritis), and tophi (tophaceous gout) [1,2].
1 Ιουλ 2008 · ABSTRACT. An elevated serum urate level, together with local factors, can result in the deposition of urate crystals into the joints. Once crystals are deposited into a joint, they can be released into the joint space and initiate an inflammatory cascade causing acute gouty arthritis.
