Αποτελέσματα Αναζήτησης
3 Ιουν 2016 · We will provide an overview of efforts to develop HSV-2 vaccines, including a discussion of the clinical need for an HSV vaccine, and status of research and development with an emphasis on recent insights from trials of vaccine candidates in clinical testing.
- Clinical management of herpes simplex virus infections: past, present ...
This vaccine comprises HSV-2 gD lacking its transmembrane...
- HSV-2 Vaccine: Current Status and Insight into Factors for Developing ...
In order to facilitate the discovery process of effective...
- Clinical management of herpes simplex virus infections: past, present ...
5 Ιαν 2012 · Two previous studies of a herpes simplex virus type 2 (HSV-2) subunit vaccine containing glycoprotein D in HSV-discordant couples revealed 73% and 74% efficacy against genital disease in...
This vaccine comprises HSV-2 gD lacking its transmembrane domain and a truncated form of infected cell polypeptide 4 (ICP4) formulated in a Matrix M-2 adjuvant. Vaccination with GEN-003 reduced shedding and severity of lesions in animal models and reduced HSV-2 shedding in human patients 37.
24 Ιαν 2014 · In order to facilitate the discovery process of effective vaccines against HSV-2, this review analyzes the key factors of developing effective vaccines and the latest progress in HSV-2 vaccine under the categories of HSV-2 pathogenesis, immune response to HSV-2, vaccine formulation, route of immunization, adjuvant and influence of sex hormones.
29 Αυγ 2024 · In this review, we comprehensively update recent breakthroughs in HSV pathogenesis and immune evasion, critically summarize the progress made in vaccine candidate development, and discuss the multifaceted applications of HSV as a biological tool.
3 Ιουν 2016 · As current control strategies for genital HSV-2 infection, including antiviral therapy and condom use, are only partially effective, vaccines will be required to reduce infection. Both preventive and therapeutic vaccines for HSV-2 are being pursued and are in various stages of development.
21 Νοε 2002 · An effective prophylactic vaccine would help control the spread of genital herpes. Methods. We conducted two double-blind, randomized trials of a herpes simplex virus type 2 (HSV-2)...
