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18 Νοε 2021 · Automated morphological analysis of bone marrow cells in microscopic images for diagnosis of leukemia: nucleus-plasma separation and cell classification using a hierarchical tree model of hematopoesis.
30 Οκτ 2023 · Histological analysis of the bone marrow will reveal an abundance of progenitor cells and their derivatives at different stages of development. Typically, the progenitor cells are larger than their end products.
Depending on need, the bone marrow microenvironment and growth factors influence pluripotent stem cells to differentiate into committed stem cells of either the myeloid or lymphoid series (multipotential stem cells), or the second stage of hematopoiesis.
18 Νοε 2021 · In this Plenary Paper, Matek et al describe training a convolutional neural network model using 171 374 bone marrow cytology images from 945 patients with various hematological diseases before validating its accuracy in classifying single cells in an independent set of 627 images.
Modern techniques of fixation, embedding and staining for conventional histology as well as immunohistology and histomorphometry enable accurate assessment of bone and bone marrow structure, architecture and cells.
Studies indicated that BMP-2 and BMP-7 enhanced osteoblast-related markers in C3H10T1/2 cells (18, 8). On the other hand, in bone marrow stromal cell cultures, Yamaguchi et al., 1996 (19) demonstrated the effects of BMP-2 on osteoblastic differentiation differ among cell types.
This article aims to familiarize the reader with the basic structure and function of the bone marrow and normal morphology of haematopoietic cells. Keywords aspirate vs trephine biopsy; haematopoietic reserve; microenvironment; normal haematopoiesis; stimulatory and inhibitory factors.
