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30 Οκτ 2023 · Histological analysis of the bone marrow will reveal an abundance of progenitor cells and their derivatives at different stages of development. Typically, the progenitor cells are larger than their end products.
Depending on need, the bone marrow microenvironment and growth factors influence pluripotent stem cells to differentiate into committed stem cells of either the myeloid or lymphoid series (multipotential stem cells), or the second stage of hematopoiesis.
For many histopathologists, who are comfortable looking at lymph nodes, assessing bone marrow trephines, let alone aspirate morphology can seem daunting. This article aims to familiarize the reader with the basic structure and function of the bone marrow and normal morphology of haematopoietic cells.
The majority of cells in a marrow smear are differentiating granulocytes, monocytes, and erythroid cells. In normal marrow, neutrophils are the most numerous with monocytes, eosinophils, and basophils collectively accounting for only 5% to 10% of the total myelomonocytic cells.
Knowledge and understanding of the appearance of normal bone marrow (BM) and therefore normal haematopoiesis is essential for both general pathologists and specialist haematopathologists. It is only once normal cytology and histology is understood that abnormalities can be identified and defined, leading to the accurate diagnosis of pathologies ...
This article aims to familiarize the reader with the basic structure and function of the bone marrow and normal morphology of haematopoietic cells. Keywords aspirate vs trephine biopsy; haematopoietic reserve; microenvironment; normal haematopoiesis; stimulatory and inhibitory factors.
Bone Marrow - Normal Histology. Click on the Annotations box below each unlabelled picture to reveal the annotated versions. Annotations Expand. Annotations Expand. Back to Normal Histology. Haematolymphoid System Pathology. Home. Normal Histology. Bone Marrow – Normal Histology.
