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30 Οκτ 2023 · Histological analysis of the bone marrow will reveal an abundance of progenitor cells and their derivatives at different stages of development. Typically, the progenitor cells are larger than their end products.
27 Ιαν 2021 · Osteogenic differentiation, the process by which bone marrow mesenchymal stem/stromal (a.k.a. skeletal stem) cells and osteoprogenitors form osteoblasts, is a critical event for bone formation during development, fracture repair, and tissue maintenance.
Depending on need, the bone marrow microenvironment and growth factors influence pluripotent stem cells to differentiate into committed stem cells of either the myeloid or lymphoid series (multipotential stem cells), or the second stage of hematopoiesis.
The components involved in bone marrow histology are cortical and trabecular bone and stroma, vasculature, sinus wall layers, nerves, hematopoietic cells, and non-hematopoietic interstitial cells. Refer to Box 2, Box 3 for a checklist and list of histochemical stains used to assess bone marrow histologic specimens. Box 2.
We will focus on bone forming osteoblasts (OB), their precursors, bone marrow stromal (mesenchymal stem) cells (BMSC) a.k.a. MSC a.k.a. skeletal stem cells (SSC), and terminally differentiated stage, osteocytes (OT).
1 Μαΐ 2024 · Undifferentiated bone marrow stromal cells (BMSCs) primarily utilize oxidative phosphorylation (OXPHOS) for energy production, whereas glycolysis becomes the primary metabolic pathway when they differentiate into osteoblasts [2].
Glucose, fatty acids, and amino acids metabolism provide energy to fuel BMSC differentiation. Moreover, some well-known regulators including environmental stress, hormone drugs, and biological and pathological factors may also influence BMSC differentiation by altering metabolism.
