Αποτελέσματα Αναζήτησης
30 Οκτ 2023 · This article will review the embryology of the bone marrow as well as its histology. Additionally, the constituent cell lineages and their function will be discussed, together with clinically relevant processes and pathologies.
The quality of the marrow sections is governed by numerous variables related to specimen collection and processing and must be considered. In addition to discussing normal structure, function, and histology of bone marrow, methods for preparation and evaluation of bone marrow are presented.
Histopathology is a subjective assessment and is useful for evaluating bone marrow architecture, assessment of cellularity, estimation of M:E ratio (limited sensitivity), assessment of cell lineages, estimation of iron stores and other features (e.g., neoplasia, inflammation, pigment, infectious agents).
The main function of the marrow is production of haematopoietic cells which develop from a small group of self-propagating stem cells. Haematopoiesis is a tightly regulated process, via various stimulatory and inhibitory factors.
The bone marrow consists of (1) hematopoietic stem cells, pluripotent cells capable of self-renewal; (2) progenitor cells that evolve into more differentiated cells with each cell division; (3) precursor cells that can be identified by light microscopy (not shown, see Fig. 13-3); and (4) mature hematopoietic cells awaiting release into the ...
6 Μαΐ 2024 · Collectively, this annotated reference serves as a comprehensive map of the cellular topology of hematopoietic cells in the context of their microenvironment and demonstrates the complementarity of these two atlases to understand the cellular anatomy of human bone marrow.
Abstract. Marrow adipocytes, collectively termed marrow adipose tissue (MAT), reside in the bone marrow in close contact to bone cells and hematopoietic cells. Marrow adipocytes arise from the mesenchymal stem cell and share their origin with the osteoblastst. Shifts in the lineage allocation of the mesenchymal stromal cell could potentially ...
